SMOKINCHOICES (and other musings)

September 4, 2017

Dark-skin’s “health ruining” woe

Some of this info was in 8/28 post on Alzheimer’s

But should have been in a post all by itself.. . concerns black, brown or any darker-toned skin

Since IMO,  this information should be made known, in a larger way,  I’m putting it up again.  Want to insure I share what I have learned, with any who need to know it.   This kinda smacks of  ‘Mother Nature’ doing a dirty on darker skinned people, but I am quite sure that this is only ‘appearances’ . . that when we know enough,   or put another way – when science catches up more fully, we might actually learn that there WAS definite reason behind what we now know, is happening.  Perhaps something as simple as different indigenous people adapting to their own unique environment. . per  those requirements.  But as time wore on, being captured and enslaved, transported to other shores – -not as amenable to their natures as they had grown to be. Who knows – – it could have been in the air,  the environmental bacteria. . .or the trees and plains.   Someday, we may learn what it is or was.  

Meanwhile,  as much as we really need the cause of it so that we can be certain of how to fix it;  we do have a fix which makes it possible for any of us to experience natural good health – NATURALLY, without chemicals (drugs).  The fix has everything to do with L-Arginine, the amino acid (one of 22).  This  we get from our animal protein foods; same for everybody – – black, white!   Dark-skin function has a problem utilizing arginine even tho it has built-in, a greater capacity than light skinned people do,  to be able to do so.  There is a dysfunction which precludes this absorption and instead, is producing another harmful oxidant. . and that’s what this is all about.  So, no matter the cause, presently we CAN do something which offsets the dysfunctional end result. Take Arginine powder (available and fairly cheap). . I get mine @ Bulk Supplements but have many other online possibilities.   A 5 gm dose once or twice daily [mixed with added Citrulline to boost it], mixed in water is all ya need.  Safely used in trials up to 50 gms daily w/no side effects.  I take this every day along with bunch of other stuff. So don’t worry about safety.    It’s all about getting ‘energy’ into our cell’s Mitochondria so that we can live and do what we need and want to do.        

Have two links below to show you that this is science-based, not just Jan, blowin smoke around.  .  .   .  Hope this helps        Jan

 

When the Good and the Bad Make the Ugly: The Discovery of Peroxynitrite

R. RadiJ. S. BeckmanK. M. BushB. A. Freeman Peroxynitrite Oxidation of Sulfhydryls. The Cytotoxic Potential of Superoxide and Nitric Oxide J. Biol. Chem. 1991 266, 42444250

At first, no one took them seriously. In 1991, Rafael Radi, Joseph Beckman, Kenneth Bush, and Bruce Freeman published a paper in the Journal of Biological Chemistry (JBC) demonstrating that a molecule called peroxynitrite, the product of a reaction between nitric oxide and superoxide radicals, selectively attacked sulfhydryls in proteins. “Nobody believed much of any of it,” recalls Beckman at Oregon State University. “It was considered an unproven theory. I was surprised we even got the paper accepted in JBC.”

Figure

The original proposed mechanisms of oxygen-radical-mediated cytotoxicity. NX, a yet unidentified nitrogen-containing species; CAT, catalase; SOD, superoxide dismutase.

Today, “Peroxynitrite Oxidation of Sulfhydryls” is recognized as a JBC Classic. The paper has been cited in the scientific literature more than 2100 times.

Until 1990, the chemistries of nitric oxide and oxygen radicals were thought to be unrelated. Nitric oxide was known to physiologists as the molecular radical that caused vasodilation, played a role in neurotransmission, and killed invasive pathogens. The chemistry of superoxide and other oxygen radicals fell under the purview of biochemists interested in the damage wreaked by these reactive entities. Neither group considered that their radical of interest had anything to do with the other.

That view was challenged in 1990 with a paper in the Proceedings of the National Academy of Sciences (PNAS), with Beckman as the first author and Freeman as the corresponding author. At that time, the group was at the University of Alabama in Birmingham. Freeman held a faculty position. Beckman was a tenure-track assistant professor who had done a postdoctoral fellowship with Freeman.

In the PNAS paper, the authors described how nitric oxide reacted with superoxide to form peroxynitrite. “We proposed that nitric oxide was toxic because it reacted with superoxide to form peroxynitrite,” explains Beckman.

Radi, who had joined the Freeman group as a postdoctoral fellow, had been working on oxygen radicals at the Universidad de la República in Uruguay (he later returned to the institution as a principal investigator). For the JBC paper, he and Beckman analyzed the reaction kinetics of peroxynitrite with bovine serum albumin and cysteine and discovered that peroxynitrite was capable of directly oxidizing sulfhydryls, much more so than hydrogen peroxide. “This completely opened a new paradigm of oxygen-radical-dependent toxicity by means of the cross-talk with the nitric oxide pathway,” says Radi. Bush, the third author on the paper, was a research technician who later became a lawyer.

Radi says he and Beckman found inspiration from Clint Eastwood’s movie “The Good, The Bad, and the Ugly.” It was unthinkable to physiologists that nitric oxide could “be converted in such a nasty molecule just because of the reaction with superoxide,” says Radi. “Nitric oxide was the good guy; superoxide, the bad; and peroxynitrite, the ugly.”

These days, peroxynitrite is recognized as an oxidant and nucleophile that can attack mitochondria and lead to cell death by a slew of oxidation and nitration reactions. Radi explains that peroxynitrite has a dual personality. It can be “liberated by our immune cells to kill invading pathogens,” says Radi. However, he adds that the molecule has been implicated in atherosclerosis, hypertension, type 2 diabetes, and neurodegenerative conditions, such as amyotrophic lateral sclerosis.

Peroxynitrite can break down to form secondary molecules such as nitrogen dioxide and hydroxyl radicals. Freeman says nitrogen dioxide is capable of nitrating protein tyrosine and tryptophan residues and unsaturated fatty acids. The latter reaction leads to products with signaling capabilities that modulate metabolic and inflammatory responses. The fatty acid reaction with nitrogen dioxide is being scrutinized as a drug target.

However, back in the early 1990s, “it took a few years and redundant ways to show that these reactions were of any importance in biology,” says Radi. Beckman sees the silver lining in having naysayers: not too many others were interested in working on peroxynitrite. The field was left wide open for investigators like him, Radi, and Freeman to get a head start on peroxynitrite research. He says, “The moral here is don’t get discouraged if people don’t immediately jump to your ideas.”

Next is an excellent source for what Arginine is, why we need it   (enables Nitric Oxide, the miracle molecule to do its work enabling and protecting the complete cardiovascular system).  It’s big (or long, detailed)..can scroll down to #20 and #21 and then go down as far as you want to go.      

However, the ‘actual cause’ of why black or dark skinned people have this dysfunctional problem (of not being able to process  properly, thereby activating nitric oxide in order to prevent all these multiple and associated problems is still not known).   What is a given, L-Arginine is highly effective in use by many forward thinking (up-to-date) physicians who are changing people’s lives for the better.   It’s available now. . .L-Arginine  is out there and ready for use.  Dr Harry is the one who made this come alive for me in his book    “Lets STOP the @ 1 Killer of Americans TODAY”  Ya can’t know my pleasure that I did it myself;  still kcking around OK  (thank you Dr Harry. . .and God Bless You)            Jan

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