SMOKINCHOICES (and other musings)

November 8, 2011

Vitamin D – gotta know this

VITAMIN D3, YOU ROCK

Think you all know that I am an advocate of high-dose Vit D3 and I frankly, must acknowledge my education of it’s importance to Dr. John Cannell of the Vitamin D Council.  When I learned of it’s importance to a living organism, I asked my doctor to test me and I was found to be at 13! (so low as to be considered “0”).  She immediately put me on 50K prescription D weekly. Month or so later, was up to 40.  Great, but I wanted higher – 70 to 100.  Plus, I learned that any prescription D is going to be D2, acceptable but not ideal or what I wanted.  So I stopped Phrma D and bought my own taking 10 K daily.  Month later, was finally at 70.  Pleased and with warm weather and sunshine aplenty, dropped it down to 5,000 IU daily, where I believe I have remained (essentially).

Why was all this so important to me?  I had been afflicted deeply in the lung department of my body throughout my life, both as a child and adult.  Once, I even spent 3 months in a TB sanitarium taking dreadful, strong medication for a disease it turned out I did not have – – had only been another case of hard to cure pneumonia.  So believe me, I was so glad to learn of this deficiency within self.  As an aside, I haven’t had a cold or flu or pneumonia since starting therapeutic doses of D3.  One of those blessings I’m so grateful for.

Unless you’ve been under a rock this past year or so, you’re no doubt aware of it’s in great edge in staving off cancers and even in the battle of it if  it has already arrived.   Dr Cannell has counseled parents with autistic children and helped them to find solutions and improvement.  These are issues made better for us in our health.

But when it comes to possibly extending our chances for a longer, healthy life?. . .it’s really getting interesting. I read about the telomeres and have seen lectures of doctors trying to explain the complicated way of this action.   So today, we have Dr Cannell discussing it in very simple terms almost anyone can understand, how taking D3 helps in the process which seems to regulate how long we live by how fast and how many of those telomeres we lose as they protect the ends of the chromosomes they are attached to.  After the telomeres are gone, we are gone.  This is very, very good to know.    So on with Dr. Cannell:                Jan)

Clinical trial finds vitamin D increases telomerase activity
November 3, 2011 — Dr John Cannell
 Telomeres are regions at the end of a chromosome, which protect the end of it from deterioration, the longer the better. The telomere regions reduce the degradation of genes near the ends of chromosomes by allowing for the shortening of chromosome ends, which necessarily occurs during chromosome replication. Over time, due to numerous cell divisions over your lifetime, the telomeres become shorter.During cell division, if cells divide without telomeres, they would lose the ends of their chromosomes and the necessary information they contain. The telomeres are disposable buffers blocking the ends of the chromosomes; they are consumed during cell division, but then replenished by an enzyme, telomerase.  Telomerase deficiency is associated with aging, death, obesity, cardiovascular disease, depression and diabetes. In October, scientists at the Georgia Health Sciences University, led by Dr. Zhu, reported on the effect of vitamin D on telomerase activity in obese African Americans. They gave 60,000 IU per month for four months to one group and placebo to another group.   H, Guo D, Li K, Pedersen-White J, Stallmann-Jorgensen IS, Huang Y, Parikh S, Liu K, Dong Y. Increased telomerase activity and vitamin D supplementation in overweight African Americans. Int J Obes (Lond). 2011 Oct 11The authors found that vitamin D increased telomerase activity by 19%. The authors wrote, “Our data suggest that vitamin D may improve telomere maintenance and prevent cell senescence.”

That is, vitamin D is the repair and maintenance man of the human body. When you think about it, of all the things vitamin D does, it usually works by repairing and maintaining the human body.

One thing I didn’t understand about their study was the dose response. They gave 60,000 IU per month (about 2,000 IU/day) but reported that vitamin D levels increased from 16 to 40 ng/ml and this was a study of obese subjects. I emailed the author, and he said they drew the last blood work, 25-30 days after the last dose of vitamin D. The vitamin D levels were higher than I would have expected.

I am leery of studies that use monthly doses, although this one showed an important positive effect. Primitive man didn’t get sunshine one day a month and vitamin D levels fall the last two weeks after a monthly 60,000 IU dose, perhaps activating the enzyme that destroys activated vitamin D in the cells. I also wonder what the effect would have been if the subjects all took 2,000 IU/day (the equivalent of 60,000 IU/month). I don’t know but predict it would have been more than a 19% increase in telomerase.

Vitamin D deficiency associated with increased risk of mortality in elderly
October 31, 2011 — Dr John Cannell
Study follows older men between the ages of 70 and 81 and finds an association with mortality and 25(OH)D levels… continue reading
Evidence to support a vitamin D paradigm shift
November 2, 2011 — Dr John Cannell
Professor Joan Lappe of Creighton University writes an up to date review article on vitamin D that serves as a good primer for anyone just awakened to the “vitamin D revolution”… continue reading
Relationship between vitamin D and single nucleotide polymorphisms (SNPs) reviewed
November 4, 2011 — Dr John Cannell
Genetic variations, called single nucleotide polymorphisms (SNPs), are common in just about every protein involved with vitamin D, including the vitamin D receptor, the enzyme that makes activated vitamin D and the protein that transports vitamin D in the blood… continue reading
Forensic specialist reviews shaken baby syndrome cases
November 5, 2011 — Dr John Cannell
Forensic medical specialist Dr. Steven Gabaeff reviews shaken baby syndrome cases… continue reading
Weighing the costs and benefits of using sunbeds
November 1, 2011 — Dr John Cannell
Professor Johan Moan and colleagues from the University of Oslo compare the risk of using sunbeds to the risk of not using sunbeds… continue reading
Another study shows that vitamin D levels are inversely associated with markers of SLE disease activity
November 7, 2011 — Dr John Cannell
In March of 2011, a group from Alzahra Hospital in Isfahan, Iran, led by Dr. Bonakdar, discovered, once again, that vitamin D levels are inversely associated with markers of SLE disease activity… continue reading
No association between vitamin D and fatigue in cancer patients
October 28, 2011 — Dr John Cannell
A group from the University of Texas MD Anderson Cancer Center study whether there is an association between fatigue and loss of appetite in cancer patients… continue reading
Glucocorticoid users twice as likely to be deficient in vitamin D
October 29, 2011 — Dr John Cannell
Dr. Amy Skversky and colleagues from the Albert Einstein School of Medicine looked at 22,000 individuals,181 of which took glucocorticoids. Those 181 people were twice as likely to have severe vitamin D deficiency, levels less than 10 ng/ml… continue reading
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5 Comments »

  1. I could not refrain from commenting. Perfectly
    written!

    Comment by injectable hcg — February 6, 2013 @ 5:08 am | Reply

    • Thank you Fay. Have to admit, I am partial to Dr Cannell and the great effort he has demonstrated over time in helping people understand the importance of Vitamin D-3. He has been a blessing to this blog, and I’m sure, many thousands of others. What a guy! Jan

      Comment by Jan Turner — February 6, 2013 @ 7:02 am | Reply

  2. It’s actually a cool and useful piece of info. I am satisfied that you simply shared this useful info with us. Please keep us up to date like this. Thank you for sharing.

    Comment by phenibut — August 6, 2013 @ 5:31 pm | Reply

    • Emelia, it is in fact – my pleasure when people have found something new they can profit from. Pleased you took the time to say hello. Jan

      Comment by Jan Turner — August 6, 2013 @ 6:07 pm | Reply

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